Roles of Mitochondria and ER Stress in Metabolic Diseases and Aging

Maintenance of calcium homeostasis and control of oxidative stress in the cytosol and organelles are important for cellular function and survival. Persistent metabolic stress caused by unhealthy lifestyle deteriorates cellular and organellar functions, in particular in individuals with genetic susceptibility to type 2 diabetes. This disease affects 380 million people worldwide and is steadily increasing in the wake of the obesity epidemic. Accumulating evidence suggests pathophysiological implication of mitochondria and ER leading to irreversible loss of normal cell function. However, despite recent progress, the molecular mechanisms underlying organellar stress leading to metabolic diseases and aging remain elusive. Our project focuses on the delineation of mitochondrial stress and ER stress related to calcium overload and oxidative injury. The elucidation of these mechanisms should provide clues on therapeutic intervention to arrest disease progression. Our proposal aims to strengthen long-term close collaboration between eminent scientists with established expertise in the field with documented past collaborations. In addition to scientific advance, both universities should benefit from education of students and postdocs.

Participants : 
  • UNIGE
    • Prof. (Emeritus) Claes B. Wollheim - Department of Cell Physiology and Metabolism / Faculty of Medicine
    • Prof. Nicolas Demaurex - Department of Cell Physiology and Metabolism / Faculty of Medicine
  • Yonsei
    • Prof. Myung-Shik Lee  - Department of Internal Medicine, College of Medicine
    • Prof. Kyu-Sang Park - Department of Physiology, Wonju College of Medicine